American Airlines, Inc. (AA) is a major airline of the United States. It is the world's largest airline in passenger miles transported and passenger fleet size. A subsidiary of the AMR Corporation, the airline is headquartered in Fort Worth, Texas, adjacent to the Dallas-Fort Worth International Airport.

American operates scheduled flights throughout the United States, and flights to Canada, Latin America, the Caribbean, Europe, Japan, China, and India. In 2005, the airline flew more than 138 billion revenue passenger miles (RPM).

American has five hubs: Dallas/Fort Worth (DFW), Chicago (ORD), Miami (MIA), Lambert St Louis International Airport (STL), and Luis Muñoz Marín International Airport in San Juan, PR (SJU). Dallas/Fort Worth is the airline's largest hub, with AA operating 85 percent of flights at the airport and traveling to more destinations than from its other hubs. Los Angeles (LAX), New York-Kennedy (JFK), and Boston (BOS) serve as focus cities and international gateways. American operates maintenance bases at Tulsa (TUL), Kansas City (MCI), and Fort Worth Alliance (AFW).

American Airlines serves four continents. Hubs at Dallas/Fort Worth and Miami serve as gateways to the Americas, while American's Chicago hub has become the airline's primary gateway to Europe and Asia. New York Kennedy (JFK) is a primary gateway for both the Americas and Europe, while New York La Guardia (LGA) and St. Louis are regional hubs. It serves the second largest number of international destinations, second to Continental Airlines

American is the only U.S. airline with scheduled flights to Anguilla, Bolivia, Dominica, Grenada, Saint Vincent and the Grenadines, and Uruguay.

American planned flights between Dallas/Fort Worth and Beijing via Chicago-O'Hare (on Westbound only) in 2007 but lost its bid to United Airlines' Dulles to Beijing route. AA was granted permission in September 2007 to start a Chicago-Beijing route in a new set of China routes in 2009.

American has begun non-stop service from Miami to the Brazilian cities of Belo Horizonte, Recife, and Salvador. It has also added nonstop flights from Dallas/Fort Worth to San Salvador (Spring 2008) and Panama City, Panama (December 2007). Since then, service ended in September 2008 to San Salvador. In 2008, American also began non-stop service from Chicago to Moscow.